About Leucine-rich repeat transmembrane neuronal protein 1
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) is a protein
from Homo sapiens identified by UniProt accession
Q86UE6, 522 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Leucine-rich repeat transmembrane neuronal protein 1 |
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| UniProt accession | Q86UE6 |
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| Gene | LRRTM1 |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.24
- Alzheimer disease · score 0.21
- cognitive function measurement · score 0.19
- amyloid-beta measurement · score 0.17
- attention deficit hyperactivity disorder · score 0.14
- substance abuse · score 0.13
- antisocial behaviour measurement · score 0.13
- smoking status measurement · score 0.13
- metabolite measurement · score 0.12
- vital capacity · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UE6-F1 | alphafold | PREDICTED | 78.55 | — |
Amino-acid sequence (522 residues)
MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG EDVLDAVYAF HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV
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