Glycerol-3-phosphate acyltransferase 4 (GPAT4)

About Glycerol-3-phosphate acyltransferase 4

Glycerol-3-phosphate acyltransferase 4 (GPAT4) is a protein from Homo sapiens identified by UniProt accession Q86UL3, 456 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Glycerol-3-phosphate acyltransferase 4
UniProt accession	Q86UL3
Gene	GPAT4
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
mean platelet volume · score 0.09
mean corpuscular volume · score 0.04
type 2 diabetes mellitus · score 0.04
Obesity · score 0.03
nonpapillary renal cell carcinoma · score 0.03
inherited lipid metabolism disorder · score 0.02
Insulin resistance · score 0.01
Sepsis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UL3-F1	alphafold	PREDICTED	85.34	—

Amino-acid sequence (456 residues)

MFLLLPFDSL IVNLLGISLT VLFTLLLVFI IVPAIFGVSF GIRKLYMKSL LKIFAWATLR MERGAKEKNH QLYKPYTNGI IAKDPTSLEE EIKEIRRSGS SKALDNTPEF ELSDIFYFCR KGMETIMDDE VTKRFSAEEL ESWNLLSRTN YNFQYISLRL TVLWGLGVLI RYCFLLPLRI ALAFTGISLL VVGTTVVGYL PNGRFKEFMS KHVHLMCYRI CVRALTAIIT YHDRENRPRN GGICVANHTS PIDVIILASD GYYAMVGQVH GGLMGVIQRA MVKACPHVWF ERSEVKDRHL VAKRLTEHVQ DKSKLPILIF PEGTCINNTS VMMFKKGSFE IGATVYPVAI KYDPQFGDAF WNSSKYGMVT YLLRMMTSWA IVCSVWYLPP MTREADEDAV QFANRVKSAI ARQGGLVDLL WDGGLKREKV KDTFKEEQQK LYSKMIVGNH KDRSRS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards