Reticulon-4 receptor-like 1 (RTN4RL1)

About Reticulon-4 receptor-like 1

Reticulon-4 receptor-like 1 (RTN4RL1) is a protein from Homo sapiens identified by UniProt accession Q86UN2, 441 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Reticulon-4 receptor-like 1
UniProt accession	Q86UN2
Gene	RTN4RL1
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

body mass index · score 0.42
lean body mass · score 0.41
body fat percentage · score 0.37
fat body mass · score 0.32
body weight · score 0.30
snoring measurement · score 0.29
visceral adipose tissue measurement · score 0.28
base metabolic rate measurement · score 0.27
gait measurement · score 0.26
bipolar disorder · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UN2-F1	alphafold	PREDICTED	75.96	—

Amino-acid sequence (441 residues)

MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards