Reticulon-4 receptor-like 2 (RTN4RL2)

About Reticulon-4 receptor-like 2

Reticulon-4 receptor-like 2 (RTN4RL2) is a protein from Homo sapiens identified by UniProt accession Q86UN3, 420 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Reticulon-4 receptor-like 2
UniProt accession	Q86UN3
Gene	RTN4RL2
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
anxiety · score 0.04
mathematical ability · score 0.04
neoplasm · score 0.04
experimental autoimmune encephalomyelitis · score 0.03
congenital dyserythropoietic anemia type 4 · score 0.03
Congenital dyserythropoietic anemia type IV · score 0.03
eosinophil count · score 0.03
hemoglobin D disease · score 0.03
hepatorenocardiac degenerative fibrosis · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UN3-F1	alphafold	PREDICTED	79.00	—

Amino-acid sequence (420 residues)

MLPGLRRLLQ APASACLLLM LLALPLAAPS CPMLCTCYSS PPTVSCQANN FSSVPLSLPP STQRLFLQNN LIRTLRPGTF GSNLLTLWLF SNNLSTIYPG TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFRGLSRLT ILYLFNNSLA SLPGEALADL PSLEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR ALREADFQAC PPAAPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQMCPGAAC QAPPDSRGPA LSAGLPSPLL CLLLLVPHHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards