About Zinc finger homeobox protein 4
Zinc finger homeobox protein 4 (ZFHX4) is a protein
from Homo sapiens identified by UniProt accession
Q86UP3, 3567 residues long.
MolForge cross-references it against 0 known binders and
203 disease associations.
Target properties
| Protein name | Zinc finger homeobox protein 4 |
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| UniProt accession | Q86UP3 |
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| Gene | ZFHX4 |
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| Organism | Homo sapiens |
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| Length | 3567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (203)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.48
- Neurodevelopmental disorder · score 0.45
- body height · score 0.43
- fat body mass · score 0.41
- basal cell carcinoma · score 0.40
- non-melanoma skin carcinoma · score 0.40
- refractive error measurement · score 0.38
- skin cancer · score 0.38
- heel bone mineral density · score 0.37
- cancer · score 0.37
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3567 residues)
METCDSPPIS RQENGQSTSK LCGTTQLDNE VPEKVAGMEP DRENSSTDDN LKTDERKSEA LLGFSVENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC PNARLPVLKD DNESEISELE DSDVENLTGE IVYQPDGSAY IIEDSKESGQ NAQTGANSKL FSTAMFLDSL ASAGEKSDQS ASAPMSFYPQ IINTFHIASS LGKPFTADQA FPNTSALAGV GPVLHSFRVY DLRHKREKDY LTSDGSAKNS CVSKDVPNNV DLSKFDGCVS DGKRKPVLMC FLCKLSFGYI RSFVTHAVHD HRMTLNDEEQ KLLSNKCVSA IIQGIGKDKE PLISFLEPKK STSVYPHFST TNLIGPDPTF RGLWSAFHVE NGDSLPAGFA FLKGSASTSS SAEQPLGITQ MPKAEVNLGG LSSLVVNTPI TSVSLSHSSS ESSKMSESKD QENNCERPKE SNVLHPNGEC PVKSEPTEPG DEDEEDAYSN ELDDEEVLGE LTDSIGNKDF PLLNQSISPL SSSVLKFIEK GTSSSSATVS DDTEKKKQTA AVRASGSVAS NYGISGKDFA DASASKDSAT AAHPSEIARG DEDSSATPHQ HGFTPSTPGT PGPGGDGSPG SGIECPKCDT VLGSSRSLGG HMTMMHSRNS CKTLKCPKCN WHYKYQQTLE AHMKEKHPEP GGSCVYCKTG QPHPRLARGE SYTCGYKPFR CEVCNYSTTT KGNLSIHMQS DKHLNNVQNL QNGNGEQVFG HSAPAPNTSL SGCGTPSPSK PKQKPTWRCE VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ NMKQIQHNLH LGLAPAEAEL YQYYLAQNIG LTGMKLENPA DPQLMINPFQ LDPATAAALA PGLGELSPYI SDPALKLFQC AVCNKFTSDS LEALSVHVSS ERSLPEEEWR AVIGDIYQCK LCNYNTQLKA NFQLHCKTDK HMQKYQLVAH IKEGGKSNEW RLKCIAIGNP VHLKCNACDY YTNSVDKLRL HTTNHRHEAA LKLYKHLQKQ EGAVNPESCY YYCAVCDYTT KVKLNLVQHV RSVKHQQTEG LRKLQLHQQG LAPEEDNLSE IFFVKDCPPN ELETASLGAR TCDDDLTEQH EEAEGAIKPT AVAEDDEKDT SERDNSEGKN SNKDSVSVAG GTQPLLLAKE EDVATKRSKP TEDNKFCHEQ FYQCPYCNYN SRDQSRIQMH VLSQHSVQPV ICCPLCQDVL SNKMHLQLHL THLHSVSPDC VEKLLMTVPV PDVMMPNSML LPAAASEKSE RDTPAAVTAE GSGKYSGESP MDDKSMAGLE DSKANVEVKN EEQKPTKEPL EVSEWNKNSS KDVKIPDTLQ DQLNEQQKRQ PLSVSDRHVY KYRCNHCSLA FKTMQKLQIH SQYHAIRAAT MCNLCQRSFR TFQALKKHLE AGHPELSEAE LQQLYASLPV NGELWAESET MSQDDHGLEQ EMEREYEVDH EGKASPVGSD SSSIPDDMGS EPKRTLPFRK GPNFTMEKFL DPSRPYKCTV CKESFTQKNI LLVHYNSVSH LHKLKKVLQE ASSPVPQETN SNTDNKPYKC SICNVAYSQS STLEIHMRSV LHQTKARAAK LEPSGHVAGG HSIAANVNSP GQGMLDSMSL AAVNSKDTHL DAKELNKKQT PDLISAQPAH HPPQSPAQIQ MQLQHELQQQ AAFFQPQFLN PAFLPHFPMT PEALLQFQQP QFLFPFYIPG TEFSLGPDLG LPGSATFGMP GMTGMAGSLL EDLKQQIQTQ HHVGQTQLQI LQQQAQQYQA TQPQLQPQKQ QQQPPPPQQQ QQQQASKLLK QEQSNIVSAD CQIMKDVPSY KEAEDISEKP EKPKQEFISE GEGLKEGKDT KKQKSLEPSI PPPRIASGAR GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENTDK LECGTCGKLF SNVLILKSHQ EHVHGQFFPY AALEKFARQY REAYDKLYPI SPSSPETPPP PPPPPPLPPA PPQPSSMGPV KIPNTVSTPL QAPPPTPPPP PPPPPPPPPP PPPPPPSAPP QVQLPVSLDL PLFPSIMMQP VQHPALPPQL ALQLPQMDAL SADLTQLCQQ QLGLDPNFLR HSQFKRPRTR ITDDQLKILR AYFDINNSPS EEQIQEMAEK SGLSQKVIKH WFRNTLFKER QRNKDSPYNF SNPPITVLED IRIDPQPTSL EHYKSDASFS KRSSRTRFTD YQLRVLQDFF DTNAYPKDDE IEQLSTVLNL PTRVIVVWFQ NARQKARKSY ENQAETKDNE KRELTNERYI RTSNMQYQCK KCNVVFPRIF DLITHQKKQC YKDEDDDAQD ESQTEDSMDA TDQVVYKHCT VSGQTDAAKN AAAPAASSGS GTSTPLIPSP KPEPEKTSPK PEYPAEKPKQ SDPSPPSQGT KPALPLASTS SDPPQASTAQ PQPQPQPPKQ PQLIGRPPSA SQTPVPSSPL QISMTSLQNS LPPQLLQYQC DQCTVAFPTL ELWQEHQHMH FLAAQNQFLH SPFLERPMDM PYMIFDPNNP LMTGQLLGSS LTQMPPQASS SHTTAPTTVA ASLKRKLDDK EDNNCSEKEG GNSGEDQHRD KRLRTTITPE QLEILYEKYL LDSNPTRKML DHIAREVGLK KRVVQVWFQN TRARERKGQF RAVGPAQSHK RCPFCRALFK AKSALESHIR SRHWNEGKQA GYSLPPSPLI STEDGGESPQ KYIYFDYPSL PLTKIDLSSE NELASTVSTP VSKTAELSPK NLLSPSSFKA ECSEDVENLN APPAEAGYDQ NKTDFDETSS INTAISDATT GDEGNTEMES TTGSSGDVKP ALSPKEPKTL DTLPKPATTP TTEVCDDKFL FSLTSPSIHF NDKDGDHDQS FYITDDPDDN ADRSETSSIA DPSSPNPFGS SNPFKSKSND RPGHKRFRTQ MSNLQLKVLK ACFSDYRTPT MQECEMLGNE IGLPKRVVQV WFQNARAKEK KFKINIGKPF MINQGGTEGT KPECTLCGVK YSARLSIRDH IFSKQHISKV RETVGSQLDR EKDYLAPTTV RQLMAQQELD RIKKASDVLG LTVQQPGMMD SSSLHGISLP TAYPGLPGLP PVLLPGMNGP SSLPGFPQNS NISAGMLGFP TSATSSPALS LSSAPTKPLL QTPPPPPPPP PPPPSSSLSG QQTEQQNKES EKKQTKPNKV KKIKEEELEA TKPEKHPKKE EKISSALSVL GKVVGETHVD PIQLQALQNA IAGDPASFIG GQFLPYFIPG FASYFTPQLP GTVQGGYFPP VCGMESLFPY GPTMPQTLAG LSPGALLQQY QQYQQNLQES LQKQQKQQQE QQQKPVQAKT SKVESDQPQN SNDASETKED KSTATESTKE EPQLESKSAD FSDTYVVPFV KYEFICRKCQ MMFTDEDAAV NHQKSFCYFG QPLIDPQETV LRVPVSKYQC LACDVAISGN EALSQHLQSS LHKEKTIKQA MRNAKEHVRL LPHSVCSPNP NTTSTSQSAA SSNNTYPHLS CFSMKSWPNI LFQASARRAA SPPSSPPSLS LPSTVTSSLC STSGVQTSLP TESCSDESDS ELSQKLEDLD NSLEVKAKPA SGLDGNFNSI RMDMFSV
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