About CUB and zona pellucida-like domain-containing protein 1
CUB and zona pellucida-like domain-containing protein 1 (CUZD1) is a protein
from Homo sapiens identified by UniProt accession
Q86UP6, 607 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | CUB and zona pellucida-like domain-containing protein 1 |
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| UniProt accession | Q86UP6 |
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| Gene | CUZD1 |
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| Organism | Homo sapiens |
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| Length | 607 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.15
- HbA1c measurement · score 0.08
- PHF-tau measurement · score 0.07
- Red cell distribution width · score 0.06
- mean corpuscular volume · score 0.05
- Hyperlipoproteinemia type 1 · score 0.03
- alcohol consumption measurement · score 0.03
- chronic pancreatitis · score 0.03
- cancer · score 0.02
- total cholesterol measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UP6-F1 | alphafold | PREDICTED | 79.22 | — |
Amino-acid sequence (607 residues)
MELVRRLMPL TLLILSCLAE LTMAEAEGNA SCTVSLGGAN MAETHKAMIL QLNPSENCTW TIERPENKSI RIIFSYVQLD PDGSCESENI KVFDGTSSNG PLLGQVCSKN DYVPVFESSS STLTFQIVTD SARIQRTVFV FYYFFSPNIS IPNCGGYLDT LEGSFTSPNY PKPHPELAYC VWHIQVEKDY KIKLNFKEIF LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS NSLTVVLSTD YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNN LQLKDPTCRP KLSNVVEFSV PLNGCGTIRK VEDQSITYTN IITFSASSTS EVITRQKQLQ IIVKCEMGHN STVEIIYITE DDVIQSQNAL GKYNTSMALF ESNSFEKTIL ESPYYVDLNQ TLFVQVSLHT SDPNLVVFLD TCRASPTSDF ASPTYDLIKS GCSRDETCKV YPLFGHYGRF QFNAFKFLRS MSSVYLQCKV LICDSSDHQS RCNQGCVSRS KRDISSYKWK TDSIIGPIRL KRDRSASGNS GFQHETHAEE TPNQPFNSVH LFSFMVLALN VVTVATITVR HFVNQRADYK YQKLQNY
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