About General transcription factor II-I repeat domain-containing protein 2A
General transcription factor II-I repeat domain-containing protein 2A (GTF2IRD2) is a protein
from Homo sapiens identified by UniProt accession
Q86UP8, 949 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | General transcription factor II-I repeat domain-containing protein 2A |
|---|
| UniProt accession | Q86UP8 |
|---|
| Gene | GTF2IRD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 949 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (36)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.44
- lymphocyte count · score 0.30
- systemic lupus erythematosus · score 0.30
- autoimmune disease · score 0.25
- body height · score 0.22
- Crohn's disease · score 0.22
- alcohol consumption measurement · score 0.20
- age at menarche · score 0.19
- neutrophil percentage of leukocytes · score 0.15
- mean corpuscular volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UP8-F1 | alphafold | PREDICTED | 72.38 | — |
Amino-acid sequence (949 residues)
MAQVAVSTLP VEEESSSETR MVVTFLVSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE RGCAFVNART DFQKDFAKYC VAEGLCEVKP PCPVNGMQVH SGETEILRKA VEDYFCFCYG KALGTTVMVP VPYEKMLRDQ SAVVVQGLPE GVAFQHPENY DLATLKWILE NKAGISFIIN RPFLGPESQL GGPGMVTDAE RSIVSPSESC GPINVKTEPM EDSGISLKAE AVSVKKESED PNYYQYNMQG SHPSSTSNEV IEMELPMEDS TPLVPSEEPN EDPEAEVKIE GNTNSSSVTN SAAGVEDLNI VQVTVPDNEK ERLSSIEKIK QLREQVNDLF SRKFGEAIGV DFPVKVPYRK ITFNPGCVVI DGMPPGVVFK APGYLEISSM RRILEAAEFI KFTVIRPLPG LELSNVGKRK IDQEGRVFQE KWERAYFFVE VQNIPTCLIC KQSMSVSKEY NLRRHYQTNH SKHYDQYMER MRDEKLHELK KGLRKYLLGS SDTECPEQKQ VFANPSPTQK SPVQPVEDLA GNLWEKLREK IRSFVAYSIA IDEITDINNT TQLAIFIRGV DENFDVSEEL LDTVPMTGTK SGNEIFSRVE KSLKNFCIDW SKLVSVASTG TPAMVDANNG LVTKLKSRVA TFCKGAELKS ICCIIHPESL CAQKLKMDHV MDVVVKSVNW ICSRGLNHSE FTTLLYELDS QYGSLLYYTE IKWLSRGLVL KRFFESLEEI DSFMSSRGKP LPQLSSIDWI RDLAFLVDMT MHLNALNISL QGHSQIVTQM YDLIRAFLAK LCLWETHLTR NNLAHFPTLK LASRNESDGL NYIPKIAELQ TEFQKRLSDF KLYESELTLF SSPFSTKIDS VHEELQMEVI DLQCNTVLKT KYDKVGIPEF YKYLWGSYPK YKHHCAKILS MFGSTYICEQ LFSIMKLSKT KYCSQLKDSQ WDSVLHIAT
Explore General transcription factor II-I repeat domain-containing protein 2A with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets