NADPH oxidase activator 1 (NOXA1)

About NADPH oxidase activator 1

NADPH oxidase activator 1 (NOXA1) is a protein from Homo sapiens identified by UniProt accession Q86UR1, 476 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	NADPH oxidase activator 1
UniProt accession	Q86UR1
Gene	NOXA1
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

pneumonia · score 0.20
lung adenocarcinoma · score 0.10
hip bone size · score 0.08
hip bone mineral density · score 0.06
chronotype measurement · score 0.04
lean body mass · score 0.04
tiredness measurement · score 0.04
circadian rhythm · score 0.03
atherosclerosis · score 0.03
mathematical ability · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UR1-F1	alphafold	PREDICTED	72.09	—

Amino-acid sequence (476 residues)

MASLGDLVRA WHLGAQAVDR GDWARALHLF SGVPAPPARL CFNAGCVHLL AGDPEAALRA FDQAVTKDTC MAVGFFQRGV ANFQLARFQE ALSDFWLALE QLRGHAAIDY TQLGLRFKLQ AWEVLHNVAS AQCQLGLWTE AASSLREAMS KWPEGSLNGL DSALDQVQRR GSLPPRQVPR GEVFRPHRWH LKHLEPVDFL GKAKVVASAI PDDQGWGVRP QQPQGPGANH DARSLIMDSP RAGTHQGPLD AETEVGADRC TSTAYQEQRP QVEQVGKQAP LSPGLPAMGG PGPGPCEDPA GAGGAGAGGS EPLVTVTVQC AFTVALRARR GADLSSLRAL LGQALPHQAQ LGQLSYLAPG EDGHWVPIPE EESLQRAWQD AAACPRGLQL QCRGAGGRPV LYQVVAQHSY SAQGPEDLGF RQGDTVDVLC EVDQAWLEGH CDGRIGIFPK CFVVPAGPRM SGAPGRLPRS QQGDQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards