About Gametogenetin
Gametogenetin (GGN) is a protein
from Homo sapiens identified by UniProt accession
Q86UU5, 652 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Gametogenetin |
|---|
| UniProt accession | Q86UU5 |
|---|
| Gene | GGN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 652 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (20)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.37
- prostate carcinoma · score 0.05
- hepatocellular carcinoma · score 0.05
- FRAXF syndrome · score 0.05
- D dimer measurement · score 0.05
- AIDS dementia · score 0.03
- platelet count · score 0.02
- Crohn's disease · score 0.02
- urinary bladder carcinoma · score 0.02
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UU5-F1 | alphafold | PREDICTED | 44.04 | — |
Amino-acid sequence (652 residues)
MGNLQSEPSA GGGSRKVQPS DRAPDSRRTS LVEPEMTSQA MRLTRGLGVW FPGSATPPGL MVPREPQASP STLPLTLERP SPVMPPPEEA AAVSAPPPAP AGTLLPGPSK WQKPAGTPVP RIRRLLEASH RGQGDPPSLR PLKPPPPPRQ LSVKDTVPRA PSQFPPPLET WKPPPPLPSE RQPADRRITP ALATPASPPT ESQAGPRNQG QTAGRARGGA PPHAGEGEMA QPADSESGLS LLCKITFKSR PSLAPPAASS SLAAKASLGG GGGGGLFAAS GAISYAEVLK QGPLPPGAAR PLGEVSRGAQ EAEGGDGDGE GCSGPPSAPA SQARALPPPP YTTFPGSKPK FDWVSAPDGP ERHFRFNGAG GGIGAPRRRA AALSGPWGSP PPPPEQIHSA PGPRRPAPAL LAPPTFIFPA PTNGEPMRPG PPGLQELPPL PPPTPPPTLQ PPALQPTPLP VAPPLTPGLG HKESALAPTA APALPPALAA DQAPAPSPAP APTVAEPSPP VSAPAPAAAP IKTRTRRNKG SRAARGATRK DGLHGDGPRE RATATVPDSS GGGGGGSGAS QTGAANTRAA RHWLPFQVLN SCPCKCYCHH QPRHRRLPRN VSAWLSTSTN HLGEPPWVAT IKLSGSLVAK LEHYDLQATH SN
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