Tripartite motif-containing protein 73 (TRIM73)

About Tripartite motif-containing protein 73

Tripartite motif-containing protein 73 (TRIM73) is a protein from Homo sapiens identified by UniProt accession Q86UV7, 250 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 73
UniProt accession	Q86UV7
Gene	TRIM73
Organism	Homo sapiens
Length	250 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
neutrophil percentage of granulocytes · score 0.06
hypertension · score 0.05
lean body mass · score 0.04
inflammatory bowel disease 30 · score 0.04
eosinophil count · score 0.04
fat body mass · score 0.04
CDH1-related diffuse gastric and lobular breast cancer syndrome · score 0.03
NK-cell enteropathy · score 0.03
base metabolic rate measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UV7-F1	alphafold	PREDICTED	88.57	—

Amino-acid sequence (250 residues)

MAWQVSLLEL EDRLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards