About Calcium-dependent secretion activator 2
Calcium-dependent secretion activator 2 (CADPS2) is a protein
from Homo sapiens identified by UniProt accession
Q86UW7, 1296 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Calcium-dependent secretion activator 2 |
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| UniProt accession | Q86UW7 |
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| Gene | CADPS2 |
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| Organism | Homo sapiens |
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| Length | 1296 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (129)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.22
- lysosomal storage disease · score 0.21
- multiple sclerosis · score 0.21
- Alzheimer disease · score 0.21
- neurodegenerative disease · score 0.21
- self reported educational attainment · score 0.20
- lean body mass · score 0.20
- body height · score 0.20
- facial morphology measurement · score 0.20
- age at menarche · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UW7-F1 | alphafold | PREDICTED | 78.97 | — |
Amino-acid sequence (1296 residues)
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ LLKERFQAFL NGETQIVADE AFCNAVRSYY EVFLKSDRVA RMVQSGGCSA NDFREVFKKN IEKRVRSLPE IDGLSKETVL SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY EMFQQILGIK KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD ENEIQLSKSD VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD QAEASRPQWG TQGDFTTTHP RPVVKVKLFT ESTGVLALED KELGRVILYP TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV RMDKPAHMKH SGYLYALGQK VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG YTVDYTDPHP GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL QRQTLDHRLN DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM EHSENGAVID PTLLHYSFAF CASHVHGNRP DGIGTVSVEE KERFEEIKER LSSLLENQIS HFRYCFPFGR PEGALKATLS LLERVLMKDI ATPIPAEEVK KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI LHLAELCIEV LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI HRGFEQETWQ PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY ESTNGSATSE DLFWKLDALQ MFVFDLHWPE QEFAHHLEQR LKLMASDMLE ACVKRTRTAF ELKLQKASKT TDLRIPASVC TMFNVLVDAK KQSTKLCALD GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK LSRYDEGTFF SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG
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