Hyaluronan and proteoglycan link protein 4 (HAPLN4)

About Hyaluronan and proteoglycan link protein 4

Hyaluronan and proteoglycan link protein 4 (HAPLN4) is a protein from Homo sapiens identified by UniProt accession Q86UW8, 402 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Hyaluronan and proteoglycan link protein 4
UniProt accession	Q86UW8
Gene	HAPLN4
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

HMG CoA reductase inhibitor use measurement · score 0.22
C-reactive protein measurement · score 0.15
triglyceride measurement · score 0.14
bipolar disorder · score 0.14
low density lipoprotein cholesterol measurement · score 0.13
total cholesterol measurement · score 0.13
body mass index · score 0.12
hemoglobin measurement · score 0.12
aspartate aminotransferase measurement · score 0.12
cortical surface area measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UW8-F1	alphafold	PREDICTED	80.91	—

Amino-acid sequence (402 residues)

MVCARAALGP GALWAAAWGV LLLTAPAGAQ RGRKKVVHVL EGESGSVVVQ TAPGQVVSHR GGTIVLPCRY HYEAAAHGHD GVRLKWTKVV DPLAFTDVFV ALGPQHRAFG SYRGRAELQG DGPGDASLVL RNVTLQDYGR YECEVTNELE DDAGMVKLDL EGVVFPYHPR GGRYKLTFAE AQRACAEQDG ILASAEQLHA AWRDGLDWCN AGWLRDGSVQ YPVNRPREPC GGLGGTGSAG GGGDANGGLR NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV AKVGQLFAAW KLQLLDRCTA GWLADGSARY PIVNPRARCG GRRPGVRSLG FPDATRRLFG VYCYRAPGAP DPAPGGWGWG WAGGGGWAGG ARDPAAWTPL HV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards