About Fermitin family homolog 3
Fermitin family homolog 3 (FERMT3) is a protein
from Homo sapiens identified by UniProt accession
Q86UX7, 667 residues long.
MolForge cross-references it against 0 known binders and
275 disease associations.
Target properties
| Protein name | Fermitin family homolog 3 |
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| UniProt accession | Q86UX7 |
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| Gene | FERMT3 |
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| Organism | Homo sapiens |
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| Length | 667 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (275)
Diseases linked to this target (Open Targets).
- leukocyte adhesion deficiency 3 · score 0.71
- Leukocyte adhesion deficiency type III · score 0.69
- leukocyte adhesion deficiency · score 0.63
- reticulocyte measurement · score 0.51
- reticulocyte count · score 0.43
- Immature Reticulocyte Fraction Measurement · score 0.31
- breast adenocarcinoma · score 0.25
- Parkinson disease · score 0.23
- multiple sclerosis · score 0.23
- neurodegenerative disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UX7-F1 | alphafold | PREDICTED | 82.93 | — |
Amino-acid sequence (667 residues)
MAGMKTASGD YIDSSWELRV FVGEEDPEAE SVTLRVTGES HIGGVLLKIV EQINRKQDWS DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV ILRLPNRRAL RLRASFSQPL FQAVAAICRL LSIRHPEELS LLRAPEKKEK KKKEKEPEEE LYDLSKVVLA GGVAPALFRG MPAHFSDSAQ TEACYHMLSR PQPPPDPLLL QRLPRPSSLS DKTQLHSRWL DSSRCLMQQG IKAGDALWLR FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH INKLSQSGEV GEPAGTDPGL DDLDVALSNL EVKLEGSAPT DVLDSLTTIP ELKDHLRIFR IPRRPRKLTL KGYRQHWVVF KETTLSYYKS QDEAPGDPIQ QLNLKGCEVV PDVNVSGQKF CIKLLVPSPE GMSEIYLRCQ DEQQYARWMA GCRLASKGRT MADSSYTSEV QAILAFLSLQ RTGSGGPGNH PHGPDASAEG LNPYGLVAPR FQRKFKAKQL TPRILEAHQN VAQLSLAEAQ LRFIQAWQSL PDFGISYVMV RFKGSRKDEI LGIANNRLIR IDLAVGDVVK TWRFSNMRQW NVNWDIRQVA IEFDEHINVA FSCVSASCRI VHEYIGGYIF LSTRERARGE ELDEDLFLQL TGGHEAF
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