About Zinc finger protein castor homolog 1
Zinc finger protein castor homolog 1 (CASZ1) is a protein
from Homo sapiens identified by UniProt accession
Q86V15, 1759 residues long.
MolForge cross-references it against 0 known binders and
255 disease associations.
Target properties
| Protein name | Zinc finger protein castor homolog 1 |
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| UniProt accession | Q86V15 |
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| Gene | CASZ1 |
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| Organism | Homo sapiens |
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| Length | 1759 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (255)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy · score 0.48
- systolic blood pressure · score 0.47
- diastolic blood pressure · score 0.47
- pulse pressure measurement · score 0.46
- hypertension · score 0.46
- mean arterial pressure · score 0.45
- alcohol drinking · score 0.45
- Varicose veins · score 0.44
- cardiovascular disease · score 0.43
- appendicular lean mass · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86V15-F1 | alphafold | PREDICTED | 51.96 | — |
Amino-acid sequence (1759 residues)
MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA GSHTEGSPSQ PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP APTPVLGRIA REGLELPPEG VYMVQPQGCS DEEDHAEEPS KDGGALEEKD SDGAASKEDS GPSTRQASGE ASSLRDYAAS TMTEFLGMFG YDDQNTRDEL ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE EYIRKLKAGE QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF KPGEGSPDMG GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL ASVPSAPSAP GPGPEPPASL SFNTPEYLKS TFSKTDSITT GTVSTVKNGL PTDKPAVTED VNIYQKYIAR FSGSQHCGHI HCAYQYREHY HCLDPECNYQ RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH GCHLNGKSTH YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK YEECKYEGCV YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS GALGLPPSLL GAKDTEHEES SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS LAAATAATEA GPSATKPPNS KISGLLPQGL PGSIPLALAL SNSGLPTPTP YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV ASGAGDSAPV AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN SSLLSSLMNK MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE KLAEPWKVYL RRFGTKDFCD GQCDFLHKAH FHCVVEECGA LFSTLDGAIK HANFHFRTEG GAAKGNTEAA FPASAAETKP PMAPSSPPVP PVTTATVSSL EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP ASPLATTSLE NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET DECMDYTGCS PGAMSSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDAACQF SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ FSSSADCAVP DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER GEPAAEGPAP GPPISLDGSL SLGAEPGSLL FLQSAAAGLG LALGDAGDPG PPDAAAPGPR EGAAAAAAAA GESSQEDEEE ELELPEEEAE DDEDEDDDED DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL AALAALGAPG PAPTAASSP
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