About Shieldin complex subunit 2
Shieldin complex subunit 2 (SHLD2) is a protein
from Homo sapiens identified by UniProt accession
Q86V20, 835 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Shieldin complex subunit 2 |
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| UniProt accession | Q86V20 |
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| Gene | SHLD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 835 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.47
- gout · score 0.42
- hemoglobin measurement · score 0.41
- uric acid measurement · score 0.41
- hematocrit · score 0.39
- erythrocyte count · score 0.38
- red blood cell density measurement · score 0.35
- urolithiasis · score 0.35
- creatinine measurement · score 0.32
- glomerular filtration rate · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86V20-F1 | alphafold | PREDICTED | 55.75 | — |
Amino-acid sequence (835 residues)
MSGGSQVHIF WGAPIAPLKI TVSEDTASLM SVADPWKKIQ LLYSQHSLYL KDEKQHKNLE NYKVPESIGS PDLSGHFLAN CMNRHVHVKD DFVRSVSETQ NIESQKIHSS RLSDITSSNM QICGFKSTVP HFTEEEKYQK LLSENKIRDE QPKHQPDICG KNFNTNLFQL GHKCAAVLDL VCSTEKINIG PEVVQRECVP TEYHEIQNQC LGLFSSNAVD KSRSEAAVRK VSDLKISTDT EFLSIITSSQ VAFLAQKKDK RRSPVNKGNV NMETEPKASY GEIRIPEENS IQLDGFTEAY ESGQNQAYSL ELFSPVCPKT ENSRIHINSD KGLEEHTGSQ ELFSSEDELP PNEIRIELCS SGILCSQLNT FHKSAIKRSC TSEDKVGQSE ALSRVLQVAK KMKLISNGGD SAVEMDRRNV SEFKSIKKTS LIKNCDSKSQ KYNCLVMVLS PCHVKEINIK FGPNSGSKVP LATVTVIDQS ETKKKVFLWR TAAFWAFTVF LGDIILLTDV VIHEDQWIGE TVLQSTFSSQ LLNLGSYSSI QPEEYSSVVS EVVLQDLLAY VSSKHSYLRD LPPRQPQRVN SIDFVELEHL QPDVLVHAVL RVVDFTILTE AVYSYRGQKQ KKVMLTVEQA QDQHYALVLW GPGAAWYPQL QRKKGVVLIK AQISELAFPI TASQKIALNA HSSLKSIFSS LPNIVYTGCA KCGLELETDE NRIYKQCFSC LPFTMKKIYY RPALMTAIDG RHDVCIRVES KLIEKILLNI SADCLNRVIV PSSEITYGMV VADLFHSLLA VSAEPCVLKI QSLFVLDENS YPLQQDFSLL DFYPDIVKHG ANARL
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