Paraneoplastic antigen-like protein 8A (PNMA8A)

About Paraneoplastic antigen-like protein 8A

Paraneoplastic antigen-like protein 8A (PNMA8A) is a protein from Homo sapiens identified by UniProt accession Q86V59, 439 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Paraneoplastic antigen-like protein 8A
UniProt accession	Q86V59
Gene	PNMA8A
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

body height · score 0.22
C-reactive protein measurement · score 0.03
chronotype measurement · score 0.03
Stroke · score 0.02
ovarian carcinoma · score 0.01
Ataxia-telangiectasia · score 0.01
colorectal cancer · score 0.01
cystic fibrosis · score 0.01
type 1 diabetes mellitus · score 0.01
Adams-Oliver syndrome · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86V59-F1	alphafold	PREDICTED	59.67	—

Amino-acid sequence (439 residues)

MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL GPYRVLNKIF VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP TQDAEFLKNL NEFLDAEGRT WEDVVRLLQL NHPTLSQNQH QPPENWAEAL GVLLGAVVQI IFCMDAEIRS REEARAQEAA EFEEMAAWAL AAGRKVKKEP GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR SRRKKQKKNS RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV AWVSAKNPAP MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS DQKAPRGQQP AEATASTSRG PKAKPEGSPR RATNESRKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards