Integral membrane protein GPR180 (GPR180)

About Integral membrane protein GPR180

Integral membrane protein GPR180 (GPR180) is a protein from Homo sapiens identified by UniProt accession Q86V85, 440 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Integral membrane protein GPR180
UniProt accession	Q86V85
Gene	GPR180
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.46
triglyceride measurement · score 0.45
HbA1c measurement · score 0.30
sex hormone-binding globulin measurement · score 0.29
apolipoprotein A 1 measurement · score 0.17
serum alanine aminotransferase measurement · score 0.14
PHF-tau measurement · score 0.10
hair color · score 0.10
hair colour measurement · score 0.08
metabolite measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86V85-F1	alphafold	PREDICTED	81.20	—

Amino-acid sequence (440 residues)

MGGLRLLAVA LTCCWWPQGS QGKTLRGSFS STAAQDAQGQ RIGHFEFHGD HALLCVRINN IAVAVGKEAK LYLFQAQEWL KLQQSSHGYS CSEKLSKAQL TMTMNQTEHN LTVSQIPSPQ TWHVFYADKY TCQDDKENSQ VEDIPFEMVL LNPDAEGNPF DHFSAGESGL HEFFFLLVLV YFVIACIYAQ SLWQAIKKGG PMHMILKVLT TALLLQAGSA LANYIHFSSY SKDGIGVPFM GSLAEFFDIA SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVMTQSV LLLWEQFEDI SHHSYHSHHN LAGILLIVLR ICLALSLGCG LYQIITVERS TLKREFYITF AKGCILWFLC HPVLACISVI FSDYQRDKVI TIGVILCQSV SMVILYRLFL SHSLYWEVSS LSSVTLPLTI SSGHKSRPHF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards