About FHF complex subunit HOOK-interacting protein 2B
FHF complex subunit HOOK-interacting protein 2B (FHIP2B) is a protein
from Homo sapiens identified by UniProt accession
Q86V87, 743 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | FHF complex subunit HOOK-interacting protein 2B |
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| UniProt accession | Q86V87 |
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| Gene | FHIP2B |
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| Organism | Homo sapiens |
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| Length | 743 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (142)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.23
- body fat percentage · score 0.16
- body height · score 0.16
- serum alanine aminotransferase measurement · score 0.14
- cutaneous melanoma · score 0.13
- brain measurement · score 0.12
- low density lipoprotein cholesterol measurement · score 0.11
- fat body mass · score 0.11
- high density lipoprotein cholesterol measurement · score 0.11
- sex hormone-binding globulin measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86V87-F1 | alphafold | PREDICTED | 79.50 | — |
Amino-acid sequence (743 residues)
MLSRLGALLQ EAVGAREPSI DLLQAFVEHW KGITHYYIES TDESTPAKKT DIPWRLKQML DILVYEEQQQ AAAGEAGPCL EYLLQHKILE TLCTLGKAEY PPGMRQQVFQ FFSKVLAQVQ HPLLHYLSVH RPVQKLLRLG GTASGSVTEK EEVQFTTVLC SKIQQDPELL AYILEGKKIV GRKKACGEPT ALPKDTTSHG DKDCSHDGAP ARPQLDGESC GAQALNSHMP AETEELDGGT TESNLITSLL GLCQSKKSRV ALKAQENLLL LVSMASPAAA TYLVQSSACC PAIVRHLCQL YRSMPVFLDP ADIATLEGIS WRLPSAPSDE ASFPGKEALA AFLGWFDYCD HLITEAHTVV ADALAKAVAE NFFVETLQPQ LLHVSEQSIL TSTALLTAML RQLRSPALLR EAVAFLLGTD RQPEAPGDNP HTLYAHLIGH CDHLSDEISI TTLRLFEELL QKPHEGIIHS LVLRNLEGRP YVAWGSPEPE SYEDTLDLEE DPYFTDSFLD SGFQTPAKPR LAPATSYDGK TAVTEIVNSF LCLVPEEAKT SAFLEETGYD TYVHDAYGLF QECSSRVASW GWPLTPTPLD PHEPERPFFE GHFLRVLFDR MSRILDQPYS LNLQVTSVLS RLALFPHPHI HEYLLDPYIS LAPGCRSLFS VLVRVIGDLM QRIQRVPQFP GKLLLVRKQL TGQAPGEQLD HQTLLQGVVV LEEFCKELAA IAFVKFPPHD PRQNVSPAPE GQV
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