About Kelch repeat and BTB domain-containing protein 6
Kelch repeat and BTB domain-containing protein 6 (KBTBD6) is a protein
from Homo sapiens identified by UniProt accession
Q86V97, 674 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Kelch repeat and BTB domain-containing protein 6 |
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| UniProt accession | Q86V97 |
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| Gene | KBTBD6 |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.28
- eosinophil count · score 0.23
- clear cell renal carcinoma · score 0.18
- HbA1c measurement · score 0.17
- body fat percentage · score 0.15
- fat body mass · score 0.14
- waist circumference · score 0.12
- high density lipoprotein cholesterol measurement · score 0.09
- body mass index · score 0.09
- mean corpuscular hemoglobin · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86V97-F1 | alphafold | PREDICTED | 81.15 | — |
Amino-acid sequence (674 residues)
MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VERLYAASDM LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFGHRKLRS QAQSYIAQNF KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC HVAVQWLEAA PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG HPRDPFLCCD PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ PRTDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK LKEVECYNVK RNQWALVAPL PHSFLSFDLM VIRDYLYALN SKRMFCYDPS HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV RAEWRQMNNI PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS EPDSESGSSS SLSDDDFWVR VAPQ
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