About MORC family CW-type zinc finger protein 1
MORC family CW-type zinc finger protein 1 (MORC1) is a protein
from Homo sapiens identified by UniProt accession
Q86VD1, 984 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | MORC family CW-type zinc finger protein 1 |
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| UniProt accession | Q86VD1 |
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| Gene | MORC1 |
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| Organism | Homo sapiens |
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| Length | 984 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- substance abuse · score 0.20
- antisocial behaviour measurement · score 0.20
- attention deficit hyperactivity disorder · score 0.20
- smoking status measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.15
- apolipoprotein A 1 measurement · score 0.10
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failures 50 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VD1-F1 | alphafold | PREDICTED | 69.55 | — |
Amino-acid sequence (984 residues)
MDDRYPALQR AQLRLDFIHA NSTTHSFLFG ALAELLDNAR DAGAERLDVF SVDNEKLQGG FMLCFLDDGC GMSPEEASDI IYFGRSKKRL STLKFIGQYG NGLKSGSMRI GKDFILFTKK EETMTCVFFS QTFCEEESLS EVVVPMPSWL IRTRESVTDD PQKFAMELSI IYKYSPFKTE AELMQQFDVI YGKCGTLLVI YNLKLLLNGE PELDVKTDKE DILMAGALED FPARWSFRAY TSVLYFNPWM RIFIQAKRVK TKHLCYCLYR PRKYLYVTSS FKGAFKDEVK KAEEAVKIAE SILKEAQIKV NQCDRTSLSS AKDVLQRALE DVEAKQKNLK EKQRELKTAR TLSLFYGVNV ENRSQAGMFI YSNNRLIKMH EKVGSQLKLK SLLGAGVVGI VNIPLEVMEP SHNKQEFLNV QEYNHLLKVM GQYLVQYCKD TGINNRNLTL FCNEFGYQND IDVEKPLNSF QYQRRQAMGI PFIIQCDLCL KWRVLPSSTN YQEKEFFDIW ICANNPNRLE NSCHQVECLP SIPLGTMSTI SPSKNEKEKQ LRESVIKYQN RLAEQQPQPQ FIPVDEITVT STCLTSAHKE NTKTQKIRLL GDDLKHESLS SFELSASRRG QKRNIEETDS DVEYISETKI MKKSMEEKMN SQQQRIPVAL PENVKLAERS QRSQIANITT VWRAQPTEGC LKNAQAASWE MKRKQSLNFV EECKVLTEDE NTSDSDIILV SDKSNTDVSL KQEKKEIPLL NQEKQELCND VLAMKRSSSL PSWKSLLNVP MEDVNLSSGH IARVSVSGSC KVASSPASSQ STPVKETVRK LKSKLREILL YFFPEHQLPS ELEEPALSCE LEQCPEQMNK KLKMCFNQIQ NTYMVQYEKK IKRKLQSIIY DSNTRGIHNE ISLGQCENKR KISEDKLKNL RIKLALLLQK LQLGGPEGDL EQTDTYLEAL LKEDNLLFQN NLNKVTIDAR HRLPLEKNEK TSEN
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