About GPI alpha-1,2-mannosyltransferase 4
GPI alpha-1,2-mannosyltransferase 4 (PIGZ) is a protein
from Homo sapiens identified by UniProt accession
Q86VD9, 579 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | GPI alpha-1,2-mannosyltransferase 4 |
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| UniProt accession | Q86VD9 |
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| Gene | PIGZ |
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| Organism | Homo sapiens |
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| Length | 579 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- MODY · score 0.05
- viral load · score 0.04
- hyperproinsulinemia · score 0.03
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.03
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.03
- Familial partial lipodystrophy, Köbberling type · score 0.03
- familial partial lipodystrophy, Kobberling type · score 0.03
- ulcerative colitis · score 0.02
- colorectal adenocarcinoma · score 0.01
- Crohn's disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VD9-F1 | alphafold | PREDICTED | 87.12 | — |
Amino-acid sequence (579 residues)
MQICGSSVAS VAAGTSFQVL GPVCWQQLDL KMAVRVLWGG LSLLRVLWCL LPQTGYVHPD EFFQSPEVMA EDILGVQAAR PWEFYPSSSC RSVLFPLLIS GSTFWLLRLW EELGPWPGLV SGYALLVGPR LLLTALSFAL DGAVYHLAPP MGADRWNALA LLSGSYVTLV FYTRTFSNTI EGLLFTWLLV LVSSHVTWGP TRKEPAPGPR WRSWLLGGIV AAGFFNRPTF LAFAVVPLYL WGTRGATNPG LKSLTREALV LLPGAALTAA VFVATDSWYF SSPATSRNLV LTPVNFLHYN LNPQNLARHG THARLTHLAV NGFLLFGVLH AQALQAAWQR LQVGLQASAQ MGLLRALGAR SLLSSPRSYL LLLYFMPLAL LSAFSHQEAR FLIPLLVPLV LLCSPQTQPV PWKGTVVLFN ALGALLFGCL HQGGLVPGLE YLEQVVHAPV LPSTPTHYTL LFTHTYMPPR HLLHLPGLGA PVEVVDMGGT EDWALCQTLK SFTRQPACQV AGGPWLCRLF VVTPGTTRRA VEKCSFPFKN ETLLFPHLTL EDPPALSSLL SGAWRDHLSL HIVELGEET
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