About Immunoglobulin-like and fibronectin type III domain-containing protein 1
Immunoglobulin-like and fibronectin type III domain-containing protein 1 (IGFN1) is a protein
from Homo sapiens identified by UniProt accession
Q86VF2, 1251 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Immunoglobulin-like and fibronectin type III domain-containing protein 1 |
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| UniProt accession | Q86VF2 |
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| Gene | IGFN1 |
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| Organism | Homo sapiens |
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| Length | 1251 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.02
- renal cell carcinoma · score 0.02
- papillary thyroid carcinoma · score 0.01
- prostate adenocarcinoma · score 0.01
- nonpapillary renal cell carcinoma · score 0.01
- breast cancer · score 0.01
- Colon Sessile Serrated Adenoma/Polyp · score 0.01
- prostate carcinoma · score 0.01
- dengue disease · score 0.01
- Parkinson disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VF2-F1 | alphafold | PREDICTED | 77.39 | — |
Amino-acid sequence (1251 residues)
MAGKLRKSHI PGVSIWQLVE EIPEGCSTPD FEQKPVTSAL PEGKNAVFRA VVCGEPRPEV RWQNSKGDLS DSSKYKISSS PGSKEHVLQI NKLTGEDTDL YRCTAVNAYG EAACSVRLTV IEVGFRKNRK RHREPQEDLR KELMDFRKLL KKRAPPAPKK KMDLEQIWQL LMTADRKDYE KICLKYGIVD YRGMLRRLQE MKKEQEDKMA QYINTISSLR HIRVTKDGNA KFDLELDLKD SQSKIYLYKD GEMIPYGFNN QTKHCLRRLG KRYEFQIQDL RPEDSGIYQV KVEDAVVFST ELEASAIPPR VVVPLAETHC EEQGDAVFEC TLSSPCPSAA WHFRHRLLHP SDKYEVYVSP DGLTHRLVVR GARFSDMGPY SLGTGLYTSS AWLVVEAGKD KDLQSTSADH KLQSRRSGKD GRLDIYGERR DATRSSTSRY KPGTGSFSKD AQGPMGHFSQ GLADMEVQPG EAATLSCTLT SDLGPGTWFK DGVKLTTQDG VIFKQDGLVH SLFITHVQGT QAGRYTFVAG DQQSEATLTV QDSPTIAPDV TEKLREPLVV KAGKPVIVKI PFQSHLPIQA AWRKDGAEVV GSSDREAQVD LGDGYTRLCL PSAGRKDCGQ YSVTLRSEGG SVQAELTLQV IDKPDPPQGP MEVQDCHRAG VCLRWRPPRD NGGRTVECYV VERRQAGRST WLKVGEAPAD STTFTDAHVE PGRKYTFRVR AVTSEGAGEA LESEEILVAP EALPKAPSAP AILSASSQGI TLTWTAPRGP GSAHILGYLI ERRKKGSNTW TAVNDQPVPE RRWTVADVRQ GCQYEFRVTA VAPSGPGEPG PPSDAVFARD PMRPPGLVRN LQVTDRSNTS ITLSWAGPDT QEGDEAQGYV VELCSSDSLQ WLPCHVGTVP VTTYTAKGLR PGEGYFVRVT AVNEGGQSQP SALDTLVQAM PVTVCPKFLV DSSTKDLLTV KVGDTVRVPV SFEAMPMPEV TWLKDGLPLP KRSVTVTKDG LTQLLIPVAG LSDSGLYTVV LRTLQGKEVA HSFRIRVAAC PQAPGPIHLQ ENVPGTVTAE WEPSPDEAQD VPLHYAVFTR SSAHGPWHEA ADRIHTNRFT LLGILPGHEY HFRVVAKNEL GASKPSDTSQ PWCIPRQRDR FTVKAPCYRE PDLSQKPRFL VGLRSHLLPQ GCECCMSCAV QGSPRPHVTW FKNDRSLEGN PAVYSTDLLG VCSLTIPSVS PKDSGEYKAV AENTLGQAVS TATLIVIEPS T
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