Intraflagellar transport-associated protein (IFTAP)

About Intraflagellar transport-associated protein

Intraflagellar transport-associated protein (IFTAP) is a protein from Homo sapiens identified by UniProt accession Q86VG3, 221 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Intraflagellar transport-associated protein
UniProt accession	Q86VG3
Gene	IFTAP
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

3-hydroxypropylmercapturic acid measurement · score 0.37
PHF-tau measurement · score 0.26
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive · score 0.15
histiocytic medullary reticulosis · score 0.15
cortical surface area measurement · score 0.13
cortical thickness · score 0.12
high density lipoprotein cholesterol measurement · score 0.12
brain measurement · score 0.10
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VG3-F1	alphafold	PREDICTED	66.09	—

Amino-acid sequence (221 residues)

MSAHMSGLEI MDEDQLIKDV LDKFLNCHEQ TYDEEFLNTF THLSQEDHVS KRGVFGTDSS ENIFTSAKVT HKNEADDYHL RNKTIFLRTS SQCLEEQVDN FLDLEDLDMD EEIKPQMSED LLLLPGEVEQ DVSTSIPSCI PFVAQPPTCE VKPKPSVKRM DKQTEEILGD EVQLFSLDEE FDYDNVMLTS KFSPAEIENI KELCKQQKRK DTSPDLEKSC D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards