About Leucine-rich repeat transmembrane neuronal protein 4
Leucine-rich repeat transmembrane neuronal protein 4 (LRRTM4) is a protein
from Homo sapiens identified by UniProt accession
Q86VH4, 590 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Leucine-rich repeat transmembrane neuronal protein 4 |
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| UniProt accession | Q86VH4 |
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| Gene | LRRTM4 |
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| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.43
- diet measurement · score 0.35
- insomnia measurement · score 0.32
- amyloid-beta measurement · score 0.29
- DNA methylation · score 0.28
- peripheral arterial disease · score 0.28
- traffic air pollution measurement · score 0.28
- coffee consumption · score 0.28
- risk-taking behaviour · score 0.28
- attention deficit hyperactivity disorder · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VH4-F1 | alphafold | PREDICTED | 74.01 | — |
Amino-acid sequence (590 residues)
MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV SFHKIIAGSV ALFLSVAMIL LVIYVSWKRY PASMKQLQQH SLMKRRRKKA RESERQMNSP LQEYYVDYKP TNSETMDISV NGSGPCTYTI SGSRECEMPH HMKPLPYYSY DQPVIGYCQA HQPLHVTKGY ETVSPEQDES PGLELGRDHS FIATIARSAA PAIYLERIAN
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