About Leucine-rich repeat transmembrane neuronal protein 3
Leucine-rich repeat transmembrane neuronal protein 3 (LRRTM3) is a protein
from Homo sapiens identified by UniProt accession
Q86VH5, 581 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Leucine-rich repeat transmembrane neuronal protein 3 |
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| UniProt accession | Q86VH5 |
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| Gene | LRRTM3 |
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| Organism | Homo sapiens |
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| Length | 581 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.38
- wellbeing measurement · score 0.33
- adolescent idiopathic scoliosis · score 0.32
- schizophrenia · score 0.27
- intelligence · score 0.27
- essential tremor · score 0.26
- neuroticism measurement · score 0.24
- depressive symptom measurement · score 0.24
- smoking status measurement · score 0.24
- protein measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VH5-F1 | alphafold | PREDICTED | 73.67 | — |
Amino-acid sequence (581 residues)
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG ATEPGPETDA DAEHISFHKI IAGSVALFLS VLVILLVIYV SWKRYPASMK QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY VDYKPTNTET SEMLLNGTGP CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL SHKSFETNAQ EDTMETHLET ELDLSTITTA GRISDHKQQL A
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