About Phosphofurin acidic cluster sorting protein 2
Phosphofurin acidic cluster sorting protein 2 (PACS2) is a protein
from Homo sapiens identified by UniProt accession
Q86VP3, 889 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Phosphofurin acidic cluster sorting protein 2 |
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| UniProt accession | Q86VP3 |
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| Gene | PACS2 |
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| Organism | Homo sapiens |
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| Length | 889 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (103)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 66 · score 0.68
- Seizure · score 0.46
- Intellectual disability · score 0.44
- genetic disorder · score 0.41
- developmental and epileptic encephalopathy · score 0.37
- Global developmental delay · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
- infantile epileptic-dyskinetic encephalopathy · score 0.37
- developmental and epileptic encephalopathy, 1 · score 0.37
- West syndrome · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VP3-F1 | alphafold | PREDICTED | 66.30 | — |
Amino-acid sequence (889 residues)
MAERGRLGLP GAPGALNTPV PMNLFATWEV DGSSPSCVPR LCSLTLKKLV VFKELEKELI SVVIAVKMQG SKRILRSHEI VLPPSGQVET DLALTFSLQY PHFLKREGNK LQIMLQRRKR YKNRTILGYK TLAAGSISMA EVMQHPSEGG QVLSLCSSIK EAPVKAAEIW IASLSSQPID HEDSTMQAGP KAKSTDNYSE EEYESFSSEQ EASDDAVQGQ DLDEDDFDVG KPKKQRRSIV RTTSMTRQQN FKQKVVALLR RFKVSDEVLD SEQDPAEHIP EAEEDLDLLY DTLDMEHPSD SGPDMEDDDS VLSTPKPKLR PYFEGLSHSS SQTEIGSIHS ARSHKEPPSP ADVPEKTRSL GGRQPSDSVS DTVALGVPGP REHPGQPEDS PEAEASTLDV FTERLPPSGR ITKTESLVIP STRSEGKQAG RRGRSTSLKE RQAARPQNER ANSLDNERCP DARSQLQIPR KTVYDQLNHI LISDDQLPEN IILVNTSDWQ GQFLSDVLQR HTLPVVCTCS PADVQAAFST IVSRIQRYCN CNSQPPTPVK IAVAGAQHYL SAILRLFVEQ LSHKTPDWLG YMRFLVIPLG SHPVARYLGS VDYRYNNFFQ DLAWRDLFNK LEAQSAVQDT PDIVSRITQY IAGANCAHQL PIAEAMLTYK QKSPDEESSQ KFIPFVGVVK VGIVEPSSAT SGDSDDAAPS GSGTLSSTPP SASPAAKEAS PTPPSSPSVS GGLSSPSQGV GAELMGLQVD YWTAAQPADR KRDAEKKDLP VTKNTLKCTF RSLQVSRLPS SGEAAATPTM SMTVVTKEKN KKVMFLPKKA KDKDVESKSQ CIEGISRLIC TARQQQNMLR VLIDGVECSD VKFFQLAAQW SSHVKHFPIC IFGHSKATF
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