About Thioredoxin domain-containing protein 2
Thioredoxin domain-containing protein 2 (TXNDC2) is a protein
from Homo sapiens identified by UniProt accession
Q86VQ3, 553 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Thioredoxin domain-containing protein 2 |
|---|
| UniProt accession | Q86VQ3 |
|---|
| Gene | TXNDC2 |
|---|
| Organism | Homo sapiens |
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| Length | 553 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.16
- hair shape measurement · score 0.16
- basophil count · score 0.15
- peak expiratory flow · score 0.15
- balding measurement · score 0.15
- heel bone mineral density · score 0.13
- forced expiratory volume · score 0.12
- basophil percentage of leukocytes · score 0.12
- bone quantitative ultrasound measurement · score 0.10
- phenylalanine measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VQ3-F1 | alphafold | PREDICTED | 52.16 | — |
Amino-acid sequence (553 residues)
MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA ELK
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