Reticulophagy regulator 3 (RETREG3)

About Reticulophagy regulator 3

Reticulophagy regulator 3 (RETREG3) is a protein from Homo sapiens identified by UniProt accession Q86VR2, 466 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Reticulophagy regulator 3
UniProt accession	Q86VR2
Gene	RETREG3
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

Genetic central nervous system malformation · score 0.40
genetic disorder · score 0.15
type 2 diabetes mellitus · score 0.09
leukocyte count · score 0.09
lymphocyte count · score 0.09
apolipoprotein A 1 measurement · score 0.08
monocyte count · score 0.08
body weight · score 0.08
C-reactive protein measurement · score 0.07
base metabolic rate measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VR2-F1	alphafold	PREDICTED	60.99	—

Amino-acid sequence (466 residues)

MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE PLLSRVQAAL VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII VCIDQWKNKI WPEIKVPRPD ALDNESWGFV HPRLLSVPEL CHHVAEVWVS GTIFIRNVLL FKKQNPGKFC LLSCGILTFL AVLGRYVPGL LLSYLMLVTV MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE RQLRRRALHP ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS IGMPSLMYRS PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL VSQGMIQLAL SGASQPGPSG APAQRATRGF LRSPSSDLDT DAEGDDFELL DQSELSQLDP ASSRSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards