Four-jointed box protein 1 (FJX1)

About Four-jointed box protein 1

Four-jointed box protein 1 (FJX1) is a protein from Homo sapiens identified by UniProt accession Q86VR8, 437 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Four-jointed box protein 1
UniProt accession	Q86VR8
Gene	FJX1
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neoplasm · score 0.09
cancer · score 0.09
Testicular regression syndrome · score 0.05
gonorrhea · score 0.04
46,XX ovotesticular disorder of sex development · score 0.04
46,XX gonadal dysgenesis · score 0.04
46,XY complete gonadal dysgenesis · score 0.04
primary ovarian insufficiency · score 0.04
caudal duplication · score 0.04
testicular agenesis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VR8-F1	alphafold	PREDICTED	79.01	—

Amino-acid sequence (437 residues)

MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP ARSGGPAPAP RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE PRWHVSARQP RPEESAAVHG GVFWSRGLEE QVPPGFSEAQ AAAWLEAARG ARMVALERGG CGRSSNRLAR FADGTRACVR YGINPEQIQG EALSYYLARL LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSVV SLTRWLPNLT DVVVPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA GMWDKYNEPL LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP ELAALADPHA QLLQRRLDFL AKHILHCKAK YGRRSGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards