IQ domain-containing protein H (IQCH)

About IQ domain-containing protein H

IQ domain-containing protein H (IQCH) is a protein from Homo sapiens identified by UniProt accession Q86VS3, 1027 residues long. MolForge cross-references it against 0 known binders and 214 disease associations.

Target properties

Protein name	IQ domain-containing protein H
UniProt accession	Q86VS3
Gene	IQCH
Organism	Homo sapiens
Length	1027 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (214)

Diseases linked to this target (Open Targets).

BMI-adjusted waist circumference · score 0.45
vital capacity · score 0.45
eosinophil count · score 0.44
BMI-adjusted waist-hip ratio · score 0.43
smoking behavior · score 0.43
asthma · score 0.42
waist-hip ratio · score 0.41
electrocardiography · score 0.40
pulse pressure measurement · score 0.40
body fat percentage · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VS3-F1	alphafold	PREDICTED	78.01	—

Amino-acid sequence (1027 residues)

MAQNTENHDP VGSILIQIHE DLYQLKEKLT KFSPEEKGET LDIQSLETAI KRTEVGLRIH IEKYLNVVNQ NVLTTSVNDE SLYTPQASKW LLPTVIDQKS FIFPQESEGT FWQPQRQHSS SLPVFPRAKI KVSKLIKGSN ISSLTVLPSS HCTDPYFTPI PVLQADAHKG ILSMIERGLI PPTARITFQN PPITPRAAPL HSFDEARKIP TVATFTIPRE PPPSPAEVKF FPKKQRSKGK SRRSRGHHDR KAMKVKTPLR ALKSLWDYDF LIYDGVIDNT APDFLAFKEH FSLAWGGIFS LLEHVEKFLR NYAIPEVKIK GNNLVALLPE FELTNKLTRY DLLSVLEDPA HVQMLINLPG QRYKGQDGNS EAAMKIQATW KCYKARKFFL FYRQQKWASG VIAIAWLLYC HKTRLKKILK ESRQRHLENF RIRAKHLAAN WNRIRTSRRT IIHIPSLGYS QPVREHIADF NTQQNMQLGR LCDILDANVN VIYICSHHMN DELVLYYKKI LSLHAAVKSG NLEDRSDLQD RFKIITPEAV NIFPKHHMCL ATHLMYSPKA IKRIKNLIRG TEAYIVSGLL HRDDLAVADM LDIPILGSEP ELAHLYSTKS GGKRVFDSAN VAVPPGIYDI YSQQQMIEQL SQLITDHLQI QRWLFKMDSE FRGNGTAFCD IPSYLKCYKW VLKESSRYGL EDWRKKWAQE PALVKISEEL AGILAQHAQP VNEKRFPTWR KFLQTFLSQG GVIEAFPPAD NVTNLTVDML IEPNGKISVL STGDQLHAES PFISSGTTVP QTSVDPQVLT YLCLQIGKAC RMRDVVGYFS IDLVTFIDPS TLEQQVWATG LNLAYSDQLA LTQLTLYLTN GHLDCSLSTL EVPRFVPKER KKTKCMSALS MPMLATSRYA VMTTQLRHSN LSLVFHYVFL QICRAHGIGY DVEERQGTVF ILYEHLKRHK LGMLTIGEDL QGVLMTFARH LFIIHQEISA PNMQGETNFK TTIADIETIL RVTKENKMRF EEEQQSKDDK NLSKPKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards