Catechol O-methyltransferase domain-containing…

About Catechol O-methyltransferase domain-containing protein 1

Catechol O-methyltransferase domain-containing protein 1 (COMTD1) is a protein from Homo sapiens identified by UniProt accession Q86VU5, 262 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Catechol O-methyltransferase domain-containing protein 1
UniProt accession	Q86VU5
Gene	COMTD1
Organism	Homo sapiens
Length	262 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
Parkinson disease · score 0.18
Alzheimer disease · score 0.18
lysosomal storage disease · score 0.18
multiple sclerosis · score 0.18
self reported educational attainment · score 0.04
smoking initiation · score 0.03
body fat percentage · score 0.03
body mass index · score 0.03
unipolar depression · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VU5-F1	alphafold	PREDICTED	89.26	—

Amino-acid sequence (262 residues)

MTQPVPRLSV PAALALGSAA LGAAFATGLF LGRRCPPWRG RREQCLLPPE DSRLWQYLLS RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL IQAKKALDLG TFTGYSALAL ALALPADGRV VTCEVDAQPP ELGRPLWRQA EAEHKIDLRL KPALETLDEL LAAGEAGTFD VAVVDADKEN CSAYYERCLQ LLRPGGILAV LRVLWRGKVL QPPKGDVAAE CVRNLNERIR RDVRVYISLL PLGDGLTLAF KI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Catechol O-methyltransferase domain-containing protein 1 (COMTD1)