Ran-binding protein 3-like (RANBP3L)

About Ran-binding protein 3-like

Ran-binding protein 3-like (RANBP3L) is a protein from Homo sapiens identified by UniProt accession Q86VV4, 465 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Ran-binding protein 3-like
UniProt accession	Q86VV4
Gene	RANBP3L
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.26
interstitial nephritis · score 0.25
renal tubule disease · score 0.25
hypertension · score 0.24
intraocular pressure measurement · score 0.20
fat body mass · score 0.16
reticulocyte count · score 0.12
reticulocyte measurement · score 0.11
lean body mass · score 0.09
appendicular lean mass · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VV4-F1	alphafold	PREDICTED	61.27	—

Amino-acid sequence (465 residues)

MTTIPRKGSS HLPGSLHTCK LKLQEDRRQQ EKSVIAQPIF VFEKGEQTFK RPAEDTLYEA AEPECNGFPT KRVRSSSFTF HITDSQSQGV RKNNVFMTSA LVQSSVDIKS AEQGPVKHSK HVIRPAILQL PQARSCAKVR KTFGHKALES CKTKEKTNNK ISEGNSYLLS ENLSRARISV QLSTNQDFLG ATSVGCQPNE DKCSFKSCSS NFVFGENMVE RVLGTQKLTQ PQLENDSYAK EKPFKSIPKF PVNFLSSRTD SIKNTSLIES AAAFSSQPSR KCLLEKIDVI TGEETEHNVL KINCKLFIFN KTTQSWIERG RGTLRLNDTA STDCGTLQSR LIMRNQGSLR LILNSKLWAQ MKIQRANHKN VRITATDLED YSIKIFLIQA SAQDTAYLYA AIHHRLVALQ SFNKQRDVNQ AESLSETAQQ LNCESCDENE DDFIQVTKNG SDPSSWTHRQ SVACS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards