About SEC14 domain and spectrin repeat-containing protein 1
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) is a protein
from Homo sapiens identified by UniProt accession
Q86VW0, 696 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | SEC14 domain and spectrin repeat-containing protein 1 |
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| UniProt accession | Q86VW0 |
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| Gene | SESTD1 |
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| Organism | Homo sapiens |
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| Length | 696 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- optic disc size measurement · score 0.28
- protein measurement · score 0.26
- bipolar disorder · score 0.25
- response to lithium ion · score 0.25
- refractive error · score 0.24
- sex hormone-binding globulin measurement · score 0.04
- pelvis syndrome · score 0.04
- sirenomelia · score 0.03
- exstrophy-epispadias complex · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VW0-F1 | alphafold | PREDICTED | 86.06 | — |
Amino-acid sequence (696 residues)
MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES
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