About Rho guanine nucleotide exchange factor 25
Rho guanine nucleotide exchange factor 25 (ARHGEF25) is a protein
from Homo sapiens identified by UniProt accession
Q86VW2, 580 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 25 |
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| UniProt accession | Q86VW2 |
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| Gene | ARHGEF25 |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.27
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.18
- platelet count · score 0.15
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- myeloid white cell count · score 0.10
- leukocyte count · score 0.07
- platelet crit · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VW2-F1 | alphafold | PREDICTED | 67.72 | — |
Amino-acid sequence (580 residues)
MRGGHKGGRC ACPRVIRKVL AKCGCCFARG GRESYSIAGS EGSISASAAS GLAAPSGPSS GLSSGPCSPG PPGPVSGLRR WLDHSKHCLS VETEADSGQA GPYENWMLEP ALATGEELPE LTLLTTLLEG PGDKTQPPEE ETLSQAPESE EEQKKKALER SMYVLSELVE TEKMYVDDLG QIVEGYMATM AAQGVPESLR GRDRIVFGNI QQIYEWHRDY FLQELQRCLK DPDWLAQLFI KHERRLHMYV VYCQNKPKSE HVVSEFGDSY FEELRQQLGH RLQLNDLLIK PVQRIMKYQL LLKDFLKYYN RAGMDTADLE QAVEVMCFVP KRCNDMMTLG RLRGFEGKLT AQGKLLGQDT FWVTEPEAGG LLSSRGRERR VFLFEQIIIF SEALGGGVRG GTQPGYVYKN SIKVSCLGLE GNLQGDPCRF ALTSRGPEGG IQRYVLQAAD PAISQAWIKH VAQILESQRD FLNALQSPIE YQRRESQTNS LGRPRGPGVG SPGRIQLGDQ AQGSTHTPIN GSLPSLLLSP KGEVARALLP LDKQALGDIP QAPHDSPPVS PTPKTPPCQA RLAKLDEDEL
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