About Vacuolar fusion protein MON1 homolog A
Vacuolar fusion protein MON1 homolog A (MON1A) is a protein
from Homo sapiens identified by UniProt accession
Q86VX9, 652 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Vacuolar fusion protein MON1 homolog A |
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| UniProt accession | Q86VX9 |
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| Gene | MON1A |
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| Organism | Homo sapiens |
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| Length | 652 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (92)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.12
- self reported educational attainment · score 0.10
- sex hormone-binding globulin measurement · score 0.09
- urate measurement · score 0.09
- blood protein measurement · score 0.08
- heel bone mineral density · score 0.08
- age at menarche · score 0.07
- early-onset non-syndromic cataract · score 0.07
- body mass index · score 0.06
- insomnia measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VX9-F1 | alphafold | PREDICTED | 72.37 | — |
Amino-acid sequence (652 residues)
MHPGGGPSRA ERLELGLGRE RPAKAIFLHR RPGEGGGRER CLRCGHVCVR RGPGPREAVP SGRPRPDTLT PPWVRQRAVT GTFCASWTPL RNRRAQRMAT DMQRKRSSEC LDGTLTPSDG QSMERAESPT PGMAQGMEPG AGQEGAMFVH ARSYEDLTES EDGAASGDSH KEGTRGPPPL PTDMRQISQD FSELSTQLTG VARDLQEEML PGSSEDWLEP PGAVGRPATE PPREGTTEGD EEDATEAWRL HQKHVFVLSE AGKPVYSRYG SEEALSSTMG VMVALVSFLE ADKNAIRSIH ADGYKVVFVR RSPLVLVAVA RTRQSAQELA QELLYIYYQI LSLLTGAQLS HIFQQKQNYD LRRLLSGSER ITDNLLQLMA RDPSFLMGAA RCLPLAAAVR DTVSASLQQA RARSLVFSIL LARNQLVALV RRKDQFLHPI DLHLLFNLIS SSSSFREGEA WTPVCLPKFN AAGFFHAHIS YLEPDTDLCL LLVSTDREDF FAVSDCRRRF QERLRKRGAH LALREALRTP YYSVAQVGIP DLRHFLYKSK SSGLFTSPEI EAPYTSEEEQ ERLLGLYQYL HSRAHNASRP LKTIYYTGPN ENLLAWVTGA FELYMCYSPL GTKASAVSAI HKLMRWIRKE EDRLFILTPL TY
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