Testis-specific Y-encoded-like protein 5 (TSPYL5)

About Testis-specific Y-encoded-like protein 5

Testis-specific Y-encoded-like protein 5 (TSPYL5) is a protein from Homo sapiens identified by UniProt accession Q86VY4, 417 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Testis-specific Y-encoded-like protein 5
UniProt accession	Q86VY4
Gene	TSPYL5
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

estradiol measurement · score 0.28
basal cell carcinoma · score 0.27
keratinocyte carcinoma · score 0.27
migraine disorder · score 0.12
hepatocellular carcinoma · score 0.08
non-small cell lung carcinoma · score 0.07
blood protein measurement · score 0.06
cancer · score 0.06
neoplasm · score 0.05
Ataxia-telangiectasia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VY4-F1	alphafold	PREDICTED	61.86	—

Amino-acid sequence (417 residues)

MSGRSRGRKS SRAKNRGKGR AKARVRPAPD DAPRDPDPSQ YQSLGEDTQA AQVQAGAGWG GLEAAASAQL LRLGEEAACR LPLDCGLALR ARAAGDHGQA AARPGPGKAA SLSERLAADT VFVGTAGTVG RPKNAPRVGN RRGPAGKKAP ETCSTAGRGP QVIAGGRQKK GAAGENTSVS AGEEKKEERD AGSGPPATEG SMDTLENVQL KLENMNAQAD RAYLRLSRKF GQLRLQHLER RNHLIQNIPG FWGQAFQNHP QLASFLNSQE KEVLSYLNSL EVEELGLARL GYKIKFYFDR NPYFQNKVLI KEYGCGPSGQ VVSRSTPIQW LPGHDLQSLS QGNPENNRSF FGWFSNHSSI ESDKIVEIIN EELWPNPLQF YLLSEGARVE KGKEKEGRQG PGKQPMETTQ PGVSQSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards