S-geranylgeranyl-glutathione receptor P2RY8 (P2RY8)

About S-geranylgeranyl-glutathione receptor P2RY8

S-geranylgeranyl-glutathione receptor P2RY8 (P2RY8) is a protein from Homo sapiens identified by UniProt accession Q86VZ1, 359 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	S-geranylgeranyl-glutathione receptor P2RY8
UniProt accession	Q86VZ1
Gene	P2RY8
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

Burkitts lymphoma · score 0.47
diffuse large B-cell lymphoma · score 0.45
lymphoid neoplasm · score 0.41
non-Hodgkins lymphoma · score 0.37
kidney neoplasm · score 0.37
lung carcinoma · score 0.37
skin carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
Gastric Diffuse Large B-Cell Lymphoma · score 0.37
Small Intestinal Diffuse Large B-Cell Lymphoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VZ1-F1	alphafold	PREDICTED	84.27	—

Amino-acid sequence (359 residues)

MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR RMGPRSPSVI FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT VAFYANMYSS ILTMTCISVE RFLGVLYPLS SKRWRRRRYA VAACAGTWLL LLTALSPLAR TDLTYPVHAL GIITCFDVLK WTMLPSVAMW AVFLFTIFIL LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA VVLLAFVTCF APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP GLQRQESVF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards