WD repeat-containing protein 5B (WDR5B)

About WD repeat-containing protein 5B

WD repeat-containing protein 5B (WDR5B) is a protein from Homo sapiens identified by UniProt accession Q86VZ2, 330 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	WD repeat-containing protein 5B
UniProt accession	Q86VZ2
Gene	WDR5B
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.24
vital capacity · score 0.22
cystatin C measurement · score 0.21
mean corpuscular hemoglobin · score 0.20
diet measurement · score 0.19
blood protein measurement · score 0.16
total cholesterol measurement · score 0.15
diastolic blood pressure · score 0.15
systolic blood pressure · score 0.14
low density lipoprotein cholesterol measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86VZ2-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (330 residues)

MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS PNGEWLASSS ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS ASDDKTLKLW DVRSGKCLKT LKGHSNYVFC CNFNPPSNLI ISGSFDETVK IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS LIVSGSYDGL CRIWDAASGQ CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS RGRCLKTYTG HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV ISAACHPTEN LIASAALEND KTIKLWMSNH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards