About Low-density lipoprotein receptor-related protein 11
Low-density lipoprotein receptor-related protein 11 (LRP11) is a protein
from Homo sapiens identified by UniProt accession
Q86VZ4, 500 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Low-density lipoprotein receptor-related protein 11 |
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| UniProt accession | Q86VZ4 |
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| Gene | LRP11 |
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| Organism | Homo sapiens |
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| Length | 500 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.09
- blood protein measurement · score 0.09
- triple-negative breast cancer · score 0.07
- serum metabolite measurement · score 0.07
- refractive error measurement · score 0.07
- cancer · score 0.07
- neuroimaging measurement · score 0.06
- brain volume measurement · score 0.06
- brain measurement · score 0.06
- cortical thickness · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VZ4-F1 | alphafold | PREDICTED | 67.72 | — |
Amino-acid sequence (500 residues)
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS SSGKNRKEES YIFESKGDGG GGEHPAPETG AVLPLALGLA ITALLLLMVA CRLRLVKQKL KKARPITSEE SDYLINGMYL
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