About Phosphatidylcholine:ceramide cholinephosphotransferase 1
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) is a protein
from Homo sapiens identified by UniProt accession
Q86VZ5, 413 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
|---|
| UniProt accession | Q86VZ5 |
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| Gene | SGMS1 |
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| Organism | Homo sapiens |
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| Length | 413 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (202)
Diseases linked to this target (Open Targets).
- body mass index · score 0.40
- mathematical ability · score 0.39
- attention deficit hyperactivity disorder · score 0.32
- antisocial behaviour measurement · score 0.32
- substance abuse · score 0.32
- low density lipoprotein cholesterol measurement · score 0.32
- lymphocyte count · score 0.27
- body height · score 0.24
- FEV/FVC ratio · score 0.24
- sphingolipid measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86VZ5-F1 | alphafold | PREDICTED | 79.06 | — |
Amino-acid sequence (413 residues)
MKEVVYWSPK KVADWLLENA MPEYCEPLEH FTGQDLINLT QEDFKKPPLC RVSSDNGQRL LDMIETLKME HHLEAHKNGH ANGHLNIGVD IPTPDGSFSI KIKPNGMPNG YRKEMIKIPM PELERSQYPM EWGKTFLAFL YALSCFVLTT VMISVVHERV PPKEVQPPLP DTFFDHFNRV QWAFSICEIN GMILVGLWLI QWLLLKYKSI ISRRFFCIVG TLYLYRCITM YVTTLPVPGM HFNCSPKLFG DWEAQLRRIM KLIAGGGLSI TGSHNMCGDY LYSGHTVMLT LTYLFIKEYS PRRLWWYHWI CWLLSVVGIF CILLAHDHYT VDVVVAYYIT TRLFWWYHTM ANQQVLKEAS QMNLLARVWW YRPFQYFEKN VQGIVPRSYH WPFPWPVVHL SRQVKYSRLV NDT
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