About Cytochrome P450 4Z1
Cytochrome P450 4Z1 (CYP4Z1) is a protein
from Homo sapiens identified by UniProt accession
Q86W10, 505 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Cytochrome P450 4Z1 |
|---|
| UniProt accession | Q86W10 |
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| Gene | CYP4Z1 |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- neoplasm · score 0.08
- triple-negative breast cancer · score 0.04
- central nervous system cancer · score 0.03
- breast cancer · score 0.03
- urinary bladder carcinoma · score 0.03
- cancer · score 0.02
- breast carcinoma · score 0.02
- lymph node metastatic carcinoma · score 0.01
- squamous cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W10-F1 | alphafold | PREDICTED | 92.04 | — |
Amino-acid sequence (505 residues)
MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWMI RALHLFPAPP AHWFYGHKEF YPVKEFEVYH KLMEKYPCAV PLWVGPFTMF FSVHDPDYAK ILLKRQDPKS AVSHKILESW VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSESV RMMLNKWEEH IAQNSRLELF QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RWDFLDILLS AKSENTKDFS EADLQAEVKT FMFAGHDTTS SAISWILYCL AKYPEHQQRC RDEIRELLGD GSSITWEHLS QMPYTTMCIK ECLRLYAPVV NISRLLDKPI TFPDGRSLPA GITVFINIWA LHHNPYFWED PQVFNPLRFS RENSEKIHPY AFIPFSAGLR NCIGQHFAII ECKVAVALTL LRFKLAPDHS RPPQPVRQVV LKSKNGIHVF AKKVC
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