About NACHT, LRR and PYD domains-containing protein 14
NACHT, LRR and PYD domains-containing protein 14 (NLRP14) is a protein
from Homo sapiens identified by UniProt accession
Q86W24, 1093 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | NACHT, LRR and PYD domains-containing protein 14 |
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| UniProt accession | Q86W24 |
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| Gene | NLRP14 |
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| Organism | Homo sapiens |
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| Length | 1093 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- Female infertility due to fertilization defect · score 0.09
- Rare genetic female infertility · score 0.09
- female infertility due to zona pellucida defect · score 0.07
- oocyte maturation defect 11 · score 0.07
- Hydatidiform Mole · score 0.07
- female infertility due to oocyte meiotic arrest · score 0.07
- oocyte/zygote/embryo maturation arrest 17 · score 0.06
- premature ovarian failure 19 · score 0.06
- oocyte maturation defect 9 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W24-F1 | alphafold | PREDICTED | 85.32 | — |
Amino-acid sequence (1093 residues)
MADSSSSSFF PDFGLLLYLE ELNKEELNTF KLFLKETMEP EHGLTPWNEV KKARREDLAN LMKKYYPGEK AWSVSLKIFG KMNLKDLCER AKEEINWSAQ TIGPDDAKAG ETQEDQEAVL GDGTEYRNRI KEKFCITWDK KSLAGKPEDF HHGIAEKDRK LLEHLFDVDV KTGAQPQIVV LQGAAGVGKT TLVRKAMLDW AEGSLYQQRF KYVFYLNGRE INQLKERSFA QLISKDWPST EGPIEEIMYQ PSSLLFIIDS FDELNFAFEE PEFALCEDWT QEHPVSFLMS SLLRKVMLPE ASLLVTTRLT TSKRLKQLLK NHHYVELLGM SEDAREEYIY QFFEDKRWAM KVFSSLKSNE MLFSMCQVPL VCWAACTCLK QQMEKGGDVT LTCQTTTALF TCYISSLFTP VDGGSPSLPN QAQLRRLCQV AAKGIWTMTY VFYRENLRRL GLTQSDVSSF MDSNIIQKDA EYENCYVFTH LHVQEFFAAM FYMLKGSWEA GNPSCQPFED LKSLLQSTSY KDPHLTQMKC FLFGLLNEDR VKQLERTFNC KMSLKIKSKL LQCMEVLGNS DYSPSQLGFL ELFHCLYETQ DKAFISQAMR CFPKVAINIC EKIHLLVSSF CLKHCRCLRT IRLSVTVVFE KKILKTSLPT NTWDGDRITH CWQDLCSVLH TNEHLRELDL YHSNLDKSAM NILHHELRHP NCKLQKLLLK FITFPDGCQD ISTSLIHNKN LMHLDLKGSD IGDNGVKSLC EALKHPECKL QTLRLESCNL TVFCCLNISN ALIRSQSLIF LNLSTNNLLD DGVQLLCEAL RHPKCYLERL SLESCGLTEA GCEYLSLALI SNKRLTHLCL ADNVLGDGGV KLMSDALQHA QCTLKSLVLR RCHFTSLSSE YLSTSLLHNK SLTHLDLGSN WLQDNGVKLL CDVFRHPSCN LQDLELMGCV LTNACCLDLA SVILNNPNLR SLDLGNNDLQ DDGVKILCDA LRYPNCNIQR LGLEYCGLTS LCCQDLSSAL ICNKRLIKMN LTQNTLGYEG IVKLYKVLKS PKCKLQVLGL CKEAFDEEAQ KLLEAVGVSN PHLIIKPDCN YHNEEDVSWW WCF
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