About NACHT, LRR and PYD domains-containing protein 13
NACHT, LRR and PYD domains-containing protein 13 (NLRP13) is a protein
from Homo sapiens identified by UniProt accession
Q86W25, 1043 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | NACHT, LRR and PYD domains-containing protein 13 |
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| UniProt accession | Q86W25 |
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| Gene | NLRP13 |
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| Organism | Homo sapiens |
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| Length | 1043 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- birth weight · score 0.36
- parental genotype effect measurement · score 0.29
- neurodegenerative disease · score 0.23
- infection · score 0.01
- infect · score 0.01
- neoplasm · score 0.01
- toxoplasmosis · score 0.01
- Obesity · score 0.00
- cancer · score 0.00
- type 2 diabetes mellitus · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W25-F1 | alphafold | PREDICTED | 81.10 | — |
Amino-acid sequence (1043 residues)
MNFSVITCPN GGTNQGLLPY LMALDQYQLE EFKLCLEPQQ LMDFWSAPQG HFPRIPWANL RAADPLNLSF LLDEHFPKGQ AWKVVLGIFQ TMNLTSLCEK VRAEMKENVQ TQELQDPTQE DLEMLEAAAG NMQTQGCQDP NQEELDELEE ETGNVQAQGC QDPNQEEPEM LEEADHRRKY RENMKAELLE TWDNISWPKD HVYIRNTSKD EHEELQRLLD PNRTRAQAQT IVLVGRAGVG KTTLAMQAML HWANGVLFQQ RFSYVFYLSC HKIRYMKETT FAELISLDWP DFDAPIEEFM SQPEKLLFII DGFEEIIISE SRSESLDDGS PCTDWYQELP VTKILHSLLK KELVPLATLL ITIKTWFVRD LKASLVNPCF VQITGFTGDD LRVYFMRHFD DSSEVEKILQ QLRKNETLFH SCSAPMVCWT VCSCLKQPKV RYYDLQSITQ TTTSLYAYFF SNLFSTAEVD LADDSWPGQW RALCSLAIEG LWSMNFTFNK EDTEIEGLEV PFIDSLYEFN ILQKINDCGG CTTFTHLSFQ EFFAAMSFVL EEPREFPPHS TKPQEMKMLL QHVLLDKEAY WTPVVLFFFG LLNKNIAREL EDTLHCKISP RVMEELLKWG EELGKAESAS LQFHILRLFH CLHESQEEDF TKKMLGRIFE VDLNILEDEE LQASSFCLKH CKRLNKLRLS VSSHILERDL EILETSKFDS RMHAWNSICS TLVTNENLHE LDLSNSKLHA SSVKGLCLAL KNPRCKVQKL TCKSVTPEWV LQDLIIALQG NSKLTHLNFS SNKLGMTVPL ILKALRHSAC NLKYLCLEKC NLSAASCQDL ALFLTSIQHV TRLCLGFNRL QDDGIKLLCA ALTHPKCALE RLELWFCQLA APACKHLSDA LLQNRSLTHL NLSKNSLRDE GVKFLCEALG RPDGNLQSLN LSGCSFTREG CGELANALSH NHNVKILDLG ENDLQDDGVK LLCEALKPHR ALHTLGLAKC NLTTACCQHL FSVLSSSKSL VNLNLLGNEL DTDGVKMLCK ALKKSTCRLQ KLG
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