About NACHT, LRR and PYD domains-containing protein 10
NACHT, LRR and PYD domains-containing protein 10 (NLRP10) is a protein
from Homo sapiens identified by UniProt accession
Q86W26, 655 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | NACHT, LRR and PYD domains-containing protein 10 |
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| UniProt accession | Q86W26 |
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| Gene | NLRP10 |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- atopic eczema · score 0.44
- common variable immunodeficiency · score 0.05
- isolated agammaglobulinemia · score 0.05
- severe combined immunodeficiency due to CARD11 deficiency · score 0.05
- immunodeficiency 89 and autoimmunity · score 0.04
- immunodeficiency 18 · score 0.04
- inborn error of immunity · score 0.04
- immunodeficiency 25 · score 0.04
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.04
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W26-F1 | alphafold | PREDICTED | 73.45 | — |
Amino-acid sequence (655 residues)
MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV TVEALFDSGE KPSLAPSLVV LQGSAGTGKT TLARKMVLDW ATGTLYPGRF DYVFYVSCKE VVLLLESKLE QLLFWCCGDN QAPVTEILRQ PERLLFILDG FDELQRPFEE KLKKRGLSPK ESLLHLLIRR HTLPTCSLLI TTRPLALRNL EPLLKQARHV HILGFSEEER ARYFSSYFTD EKQADRAFDI VQKNDILYKA CQVPGICWVV CSWLQGQMER GKVVLETPRN STDIFMAYVS TFLPPDDDGG CSELSRHRVL RSLCSLAAEG IQHQRFLFEE AELRKHNLDG PRLAAFLSSN DYQLGLAIKK FYSFRHISFQ DFFHAMSYLV KEDQSRLGKE SRREVQRLLE VKEQEGNDEM TLTMQFLLDI SKKDSFSNLE LKFCFRISPC LAQDLKHFKE QMESMKHNRT WDLEFSLYEA KIKNLVKGIQ MNNVSFKIKH SNEKKSQSQN LFSVKSSLSH GPKEEQKCPS VHGQKEGKDN IAGTQKEAST GKGRGTEETP KNTYI
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