About Transmembrane protein adipocyte-associated 1
Transmembrane protein adipocyte-associated 1 (TPRA1) is a protein
from Homo sapiens identified by UniProt accession
Q86W33, 373 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Transmembrane protein adipocyte-associated 1 |
|---|
| UniProt accession | Q86W33 |
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| Gene | TPRA1 |
|---|
| Organism | Homo sapiens |
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| Length | 373 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (32)
Diseases linked to this target (Open Targets).
- risk-taking behaviour · score 0.31
- bone density · score 0.28
- urate measurement · score 0.28
- diastolic blood pressure · score 0.28
- risky sexual behaviour measurement · score 0.24
- self reported educational attainment · score 0.19
- intelligence · score 0.18
- mathematical ability · score 0.18
- cognitive function measurement · score 0.14
- triglyceride measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W33-F1 | alphafold | PREDICTED | 73.13 | — |
Amino-acid sequence (373 residues)
MDTLEEVTWA NGSTALPPPL APNISVPHRC LLLLYEDIGT SRVRYWDLLL LIPNVLFLIF LLWKLPSARA KIRITSSPIF ITFYILVFVV ALVGIARAVV SMTVSTSNAA TVADKILWEI TRFFLLAIEL SVIILGLAFG HLESKSSIKR VLAITTVLSL AYSVTQGTLE ILYPDAHLSA EDFNIYGHGG RQFWLVSSCF FFLVYSLVVI LPKTPLKERI SLPSRRSFYV YAGILALLNL LQGLGSVLLC FDIIEGLCCV DATTFLYFSF FAPLIYVAFL RGFFGSEPKI LFSYKCQVDE TEEPDVHLPQ PYAVARREGL EAAGAAGASA ASYSSTQFDS AGGVAYLDDI ASMPCHTGSI NSTDSERWKA INA
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