About THO complex subunit 6
THO complex subunit 6 (THOC6) is a protein
from Homo sapiens identified by UniProt accession
Q86W42, 341 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | THO complex subunit 6 |
|---|
| UniProt accession | Q86W42 |
|---|
| Gene | THOC6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 341 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- THOC6-related developmental delay-microcephaly-facial dysmorphism syndrome · score 0.77
- genetic disorder · score 0.52
- neurodegenerative disease · score 0.46
- chronic lymphocytic leukemia · score 0.10
- brain measurement · score 0.06
- Romano-Ward syndrome · score 0.04
- Wolff-Parkinson-White Syndrome · score 0.03
- familial sick sinus syndrome · score 0.03
- Brugada syndrome · score 0.03
- hypertrophic cardiomyopathy · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W42-F1 | alphafold | PREDICTED | 93.63 | — |
Amino-acid sequence (341 residues)
MERAVPLAVP LGQTEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI FSLSSALSSE AKEESKKPVV TFQAHDGPVY SMVSTDRHLL SAGDGEVKAW LWAEMLKKGC KELWRRQPPY RTSLEVPEIN ALLLVPKENS LILAGGDCQL HTMDLETGTF TRVLRGHTDY IHCLALRERS PEVLSGGEDG AVRLWDLRTA KEVQTIEVYK HEECSRPHNG RWIGCLATDS DWMVCGGGPA LTLWHLRSST PTTIFPIRAP QKHVTFYQDL ILSAGQGRCV NQWQLSGELK AQVPGSSPGL LSLSLNQQPA APECKVLTAA GNSCRVDVFT NLGYRAFSLS F
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