About RNA N(6)-adenosine-methyltransferase METTL16
RNA N(6)-adenosine-methyltransferase METTL16 (METTL16) is a protein
from Homo sapiens identified by UniProt accession
Q86W50, 562 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | RNA N(6)-adenosine-methyltransferase METTL16 |
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| UniProt accession | Q86W50 |
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| Gene | METTL16 |
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| Organism | Homo sapiens |
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| Length | 562 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- insomnia measurement · score 0.27
- mean corpuscular hemoglobin · score 0.18
- body fat percentage · score 0.17
- erythrocyte count · score 0.16
- red blood cell density measurement · score 0.15
- mean corpuscular volume · score 0.12
- hepatocellular carcinoma · score 0.10
- mean corpuscular hemoglobin concentration · score 0.08
- gonorrhea · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86W50-F1 | alphafold | PREDICTED | 78.52 | — |
Amino-acid sequence (562 residues)
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN RDLMNQLCTY IRNQIFRLVA VN
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