About Osteopetrosis-associated transmembrane protein 1
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a protein
from Homo sapiens identified by UniProt accession
Q86WC4, 334 residues long.
MolForge cross-references it against 0 known binders and
254 disease associations.
Target properties
| Protein name | Osteopetrosis-associated transmembrane protein 1 |
|---|
| UniProt accession | Q86WC4 |
|---|
| Gene | OSTM1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 334 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (254)
Diseases linked to this target (Open Targets).
- infantile osteopetrosis with neuroaxonal dysplasia · score 0.66
- Autosomal recessive malignant osteopetrosis · score 0.54
- osteopetrosis · score 0.45
- Osteopetrosis · score 0.38
- IGF-1 measurement · score 0.26
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.12
- tooth agenesis · score 0.07
- tricho-dento-osseous syndrome · score 0.07
- amelogenesis imperfecta · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WC4-F1 | alphafold | PREDICTED | 73.87 | — |
Amino-acid sequence (334 residues)
MEPGPTAAQR RCSLPPWLPL GLLLWSGLAL GALPFGSSPH RVFHDLLSEQ QLLEVEDLSL SLLQGGGLGP LSLPPDLPDL DPECRELLLD FANSSAELTG CLVRSARPVR LCQTCYPLFQ QVVSKMDNIS RAAGNTSESQ SCARSLLMAD RMQIVVILSE FFNTTWQEAN CANCLTNNSE ELSNSTVYFL NLFNHTLTCF EHNLQGNAHS LLQTKNYSEV CKNCREAYKT LSSLYSEMQK MNELENKAEP GTHLCIDVED AMNITRKLWS RTFNCSVPCS DTVPVIAVSV FILFLPVVFY LSSFLHSEQK KRKLILPKRL KSSTSFANIQ ENSN
Explore Osteopetrosis-associated transmembrane protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets