Protein phosphatase 1 regulatory subunit 27 (PPP1R27)

About Protein phosphatase 1 regulatory subunit 27

Protein phosphatase 1 regulatory subunit 27 (PPP1R27) is a protein from Homo sapiens identified by UniProt accession Q86WC6, 154 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Protein phosphatase 1 regulatory subunit 27
UniProt accession	Q86WC6
Gene	PPP1R27
Organism	Homo sapiens
Length	154 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
hematocrit · score 0.13
drug use measurement · score 0.08
self reported educational attainment · score 0.03
small cell lung carcinoma · score 0.01
peripheral arterial disease · score 0.01
diabetes mellitus · score 0.00
cancer · score 0.00
chronic myelogenous leukemia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86WC6-F1	alphafold	PREDICTED	87.70	—

Amino-acid sequence (154 residues)

MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI RTRKVSLATI HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP LHIACSDGYP DIARYLISLG ADRDATNDDG DLPSDLIDPD YKELVELFKG TTMD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards