About Protein NLRC5
Protein NLRC5 (NLRC5) is a protein
from Homo sapiens identified by UniProt accession
Q86WI3, 1866 residues long.
MolForge cross-references it against 0 known binders and
283 disease associations.
Target properties
| Protein name | Protein NLRC5 |
|---|
| UniProt accession | Q86WI3 |
|---|
| Gene | NLRC5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1866 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (283)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.45
- eosinophil count · score 0.45
- monocyte count · score 0.44
- leukocyte count · score 0.43
- neutrophil count · score 0.40
- lymphocyte percentage of leukocytes · score 0.38
- myeloid white cell count · score 0.36
- eosinophil percentage of leukocytes · score 0.35
- multiple sclerosis · score 0.27
- neutrophil percentage of leukocytes · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86WI3-F1 | alphafold | PREDICTED | 73.86 | — |
Amino-acid sequence (1866 residues)
MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF TSQLGAEGKS QPESQLHHGL KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI LRRATASLDT PEGAIMGDVK VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR LCQKWAEGHL NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK LPACLPAEAA MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR SLCAVPALCQ VACLCLHHLL PDHAPGQSVA LLPNMTQLYM QMVLALSPPG HLPTSSLLDL GEVALRGLET GKVIFYAKDI APPLIAFGAT HSLLTSFCVC TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY VTLHSRWVQR TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG LAGSKITARG ISHLVKALPL CPQLKEVSFR DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN SICVSTLLCL ARVAVTCPTV RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA QSRSLTLRLQ KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE QKGPQERAAF LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG AARLAQLLPG LGALQSLNLS ENGLSLDAVL GLVRCFSTLQ WLFRLDISFE SQHILLRGDK TSRDMWATGS LPDFPAAAKF LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL QLSCEFLSDQ SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL SANLLGDSGL RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR VREASVNLGS EQSFRIHFSR EDQAGKTLRL SECSFRPEHV SRLATGLSKS LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG LFSLRVQEPW ADRARVLSLL EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL RLAHCDLGAH HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW MLKRLDLSHL LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE ALRAATSLEE LDLSHNQIGD AGVQHLATIL PGLPELRKID LSGNSISSAG GVQLAESLVL CRRLEELMLG CNALGDPTAL GLAQELPQHL RVLHLPFSHL GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP LLRQIDLVSC KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR LDFAFFDNQP QAPWGT
Explore Protein NLRC5 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets